Rh-Polypeptide-31

Rh-Polypeptide-31 is a peptide — a short chain of amino acids — designed to mimic or support the skin's own protective proteins. It functions as an antimicrobial and skin-protecting agent, working at the molecular level to reinforce the skin's natural barriers against environmental stressors and unwanted microorganisms.This ingredient is typically used in formulations where strengthening skin resilience and maintaining a healthy microbiome are priorities. As a peptide, it operates differently from physical sunscreens or chemical UV filters; instead, it targets the skin's intrinsic defence s…

The skin operates as a complex defence system, relying on physical barriers, chemical defences, and resident immune cells to protect against pathogens and maintain homeostasis. Rh-Polypeptide-31 appears to work by either directly inhibiting microbial growth or by signalling to the skin's own immune cells to strengthen their protective function.As we age, both the epidermis and dermis thin, and the skin's ability to mount an effective immune response can decline. By supporting these native defence mechanisms, this peptide may help maintain skin integrity and reduce the impact of age-related …

Rh-Polypeptide-31 is typically found in serums, moisturisers, and targeted treatment products. Use as directed by the product instructions; it pairs well with other barrier-supporting ingredients such as ceramides and hyaluronic acid. Peptide products are generally suitable for daily use, though you should always patch-test if you have sensitive skin.

Peptides are generally well-tolerated and considered safe for topical use. As with any new ingredient, introduce it gradually if you have reactive or sensitive skin, and discontinue if signs of irritation develop.