Peptides

Rh-Polypeptide-11

INCI: RH-POLYPEPTIDE-11

Reviewed by Emma · Last updated 14 Aug 2026

A peptide that conditions and supports the skin's structural integrity

Best For Skin Types

All, Mature, Dry

Addresses

Fine lines, Elasticity, Hydration, Barrier repair

Usage Frequency

Daily

What Is Rh-Polypeptide-11?

Rh-Polypeptide-11 is a synthetic peptide — a chain of amino acids designed to mimic natural protein structures found in skin. Peptides function as signalling molecules and conditioning agents, helping to support the skin's barrier and overall appearance.

In skincare formulations, this ingredient works primarily as a skin conditioner, helping to improve texture and maintain skin suppleness. It is typically used in modest concentrations within moisturisers, serums, and treatment products.

How It Works

Peptides like Rh-Polypeptide-11 are thought to work through multiple mechanisms. They can form a conditioning film on the skin surface, improving hydration and tactile softness. At a deeper level, peptides may communicate with skin cells, potentially triggering responses that support collagen maintenance and skin resilience.

The ingredient is particularly relevant to ageing skin, where loss of structural proteins — especially collagen — contributes to visible changes. By providing amino acid-based support, peptides may help address some of the underlying causes of age-related skin changes.

Clinical Evidence & References

Research on skin ageing consistently demonstrates that both the epidermis and dermis undergo thinning with time, largely due to a decline in collagen and other structural proteins. Peptide-based ingredients are designed to address this loss through various pathways, though the evidence base for individual peptides varies considerably.

While the theoretical rationale for peptide use in skincare is sound, specific clinical data on Rh-Polypeptide-11 itself is limited in publicly available literature. General peptide research supports their role in skin conditioning and potential support for barrier function, but individual results depend on formulation, concentration, and skin type. As with many cosmetic peptides, robust comparative studies would strengthen the evidence base.

How to Use

Rh-Polypeptide-11 is typically found in serums, moisturisers, and treatment products designed for mature or condition-specific skin. It can generally be used daily as part of your regular routine, either morning or evening. Peptide products often work best when layered with complementary ingredients such as hydrators or antioxidants, and consistency of use will yield better results than occasional application.

Safety & Precautions

Peptides are generally well-tolerated by most skin types, including sensitive skin. As with any new product, perform a patch test first, particularly if you have a history of reactivity.

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