Sh-Hexapeptide-2

Sh-Hexapeptide-2 is a short-chain peptide — a fragment of amino acids — designed to function as a skin conditioning agent. Peptides are recognised by the skin as building blocks similar to those found naturally in proteins like collagen, which decline as we age.This ingredient works to support the skin's structural proteins and help maintain its conditioning properties. It is typically included in formulations at modest concentrations as part of a broader anti-aging or skin-support strategy.

As skin ages, the epidermis and dermis gradually thin, and the production of structural proteins like collagen declines. Sh-Hexapeptide-2 is thought to work by signalling the skin to support or maintain its own protein synthesis, or by helping to condition and protect existing structural proteins.Because it is a peptide — a small protein fragment — it can penetrate the outer layers of skin and interact with the skin's natural repair and maintenance mechanisms. This may help improve skin texture, hydration retention, and the appearance of fine lines over time.

Sh-Hexapeptide-2 is most effective when used as part of a consistent routine. Apply serums or treatments containing this peptide to clean skin, morning and evening, and layer with a moisturiser to enhance hydration retention. It pairs well with other anti-ageing ingredients such as retinoids or vitamin C, though introduce layered actives gradually to avoid irritation.

Peptides are generally well-tolerated and rarely sensitising. As with any new skincare ingredient, patch test first if you have sensitive or reactive skin.