Peptides

Sh-Polypeptide-22

INCI: SH-POLYPEPTIDE-22

Reviewed by Rosie · Last updated 14 Aug 2026

A peptide designed to support skin structure and hydration as part of an anti-ageing routine

Best For Skin Types

All, Mature, Dry

Addresses

Fine lines, Hydration, Loss of firmness

Usage Frequency

Daily

What Is Sh-Polypeptide-22?

Sh-Polypeptide-22 is a synthetic peptide—a short chain of amino acids—created to mimic or support natural skin proteins. Peptides are popular in skincare because they're small enough to penetrate the skin and signal cells to maintain or improve structural integrity.

This ingredient functions primarily as a skin conditioner, helping to improve hydration and support the skin's appearance. It's found in a small proportion of skincare formulations, typically at modest concentrations.

How It Works

Peptides work by communicating with skin cells. When applied topically, Sh-Polypeptide-22 is thought to signal the skin to maintain or strengthen its natural structural proteins, such as collagen. This is relevant because the dermis naturally loses collagen with age, leading to loss of firmness and the formation of wrinkles.

By supporting hydration at the skin surface and potentially encouraging the skin's own maintenance mechanisms, this peptide may help address some visible signs of ageing. However, the extent of its penetration and efficacy depends on formulation and individual skin responses.

Clinical Evidence & References

Research on skin ageing shows that loss of dermal collagen and epidermal thinning are central to visible ageing. Peptides as a category have demonstrated potential in supporting skin structure, though specific clinical data on Sh-Polypeptide-22 in particular is limited in published literature.

General peptide research suggests benefits for hydration and appearance of fine lines, but individual results vary. More targeted studies on this specific peptide would help clarify its efficacy and optimal use.

How to Use

Sh-Polypeptide-22 is typically found in serums, moisturisers, and treatment creams. For best results, apply to clean skin before heavier creams or oils, which can help with absorption. It can be used daily as part of a consistent skincare routine. Combine with other anti-ageing ingredients like niacinamide or retinol for a more comprehensive approach to supporting skin structure and hydration.

Safety & Precautions

Peptides are generally well-tolerated and have a low risk of irritation. As with any new skincare ingredient, introduce it gradually and discontinue if sensitivity develops.

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