Peptides

Sh-Polypeptide-3

INCI: SH-POLYPEPTIDE-3

Reviewed by Kate · Last updated 2 Jun 2026

A peptide that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Mature

Addresses

Fine lines, Dryness, Hydration

Usage Frequency

Daily

What Is Sh-Polypeptide-3?

Sh-Polypeptide-3 is a peptide—a short chain of amino acids—designed to function as a skin conditioning agent in cosmetic formulations. Peptides are derived from proteins and are thought to communicate with skin cells, potentially supporting natural skin maintenance processes.

This ingredient appears in a small proportion of skincare products, typically at concentrations below 1%. Its role is primarily to condition and support the skin's appearance rather than to deliver dramatic structural changes.

How It Works

Peptides work by signalling to skin cells. When applied topically, Sh-Polypeptide-3 is thought to interact with skin receptors, potentially prompting cells to maintain or support their natural functions—particularly those related to firmness and hydration.

The peptide may also have humectant properties, meaning it can attract and bind moisture to the skin, helping to improve hydration at the surface level.

Clinical Evidence & References

Research on peptides broadly suggests they can support skin conditioning and may encourage the skin's natural maintenance processes. However, specific clinical studies on Sh-Polypeptide-3 as an isolated ingredient are limited, making it difficult to quantify its individual efficacy.

General understanding of skin aging indicates that loss of dermal collagen and epidermal thinning contribute to visible signs of aging. Peptides are included in formulations on the theory that they support skin's structural resilience, though the extent of their benefit varies depending on formulation, concentration, and individual skin response.

How to Use

Sh-Polypeptide-3 is typically found in serums, moisturisers, and targeted treatments. It works well alongside other conditioning and hydrating ingredients. Apply to clean skin as part of your regular routine—there is no need for special timing or frequency adjustments when using products containing this ingredient.

Safety & Precautions

Peptides are generally well-tolerated by most skin types. As with any ingredient, patch test if you have sensitive skin or a known allergy to amino acids.

Frequently Asked Questions

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