Peptides

Sh-Polypeptide-31

INCI: SH-POLYPEPTIDE-31

Reviewed by Kate · Last updated 14 Aug 2026

A peptide that supports skin conditioning and structural integrity

Best For Skin Types

All, Dry, Mature, Sensitive

Addresses

Fine lines, Dryness, Hydration

Usage Frequency

Daily

What Is Sh-Polypeptide-31?

Sh-Polypeptide-31 is a peptide—a short chain of amino acids—used in skincare formulations primarily for skin conditioning purposes. Peptides function as signalling molecules in the skin, communicating with cells to support various physiological processes. This particular peptide is designed to help maintain skin condition and support the skin's structural proteins.

As a conditioning agent, it works to improve the texture and feel of the skin, helping formulations deliver a smoother, more refined appearance over time with regular use.

How It Works

Peptides like Sh-Polypeptide-31 are believed to communicate with skin cells through specific receptors, triggering cellular responses that support skin health and function. As amino acid chains, they can penetrate the outer layers of the skin and influence how cells behave and maintain themselves.

By supporting the skin's natural conditioning processes, this peptide helps maintain moisture retention and skin firmness, which become increasingly important as skin ages and loses collagen and elasticity naturally.

Clinical Evidence & References

Research on skin ageing shows that loss of dermal collagen and thinning of both the epidermis and dermis are primary drivers of visible ageing signs including wrinkles and laxity. Peptides are theoretically well-positioned to support skin structure, as they can communicate with cells to encourage maintenance of proteins like collagen.

However, specific clinical data on Sh-Polypeptide-31 is limited in publicly available literature. General peptide research supports their role in skin conditioning, though individual peptides vary in efficacy. More targeted studies would help clarify this ingredient's specific contribution to skin health outcomes.

How to Use

Sh-Polypeptide-31 is typically found in serums, moisturisers, and targeted treatments. Apply to clean skin morning and evening as part of your regular routine. It works well in layered routines alongside other conditioning and hydrating ingredients, and is generally compatible with most active skincare ingredients.

Safety & Precautions

Peptides are generally well-tolerated by most skin types. As with any new ingredient, patch test first if you have sensitive skin or known allergies to peptides or amino acids.

Frequently Asked Questions

From the Clinic

Not sure what your skin actually needs?

Two minutes, a few questions, and we’ll point you at what matters — no guesswork.

Take the skin quiz

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations