Tranexamoyl Dipeptide-22

Tranexamoyl Dipeptide-22 is a synthetic peptide—a short chain of amino acids—designed to interact with skin pigmentation pathways. It combines tranexamic acid chemistry with a dipeptide structure, creating a molecule intended to influence melanin production and distribution within the skin.In cosmetic formulations, this ingredient is positioned as a skin-lightening or tone-balancing agent, though it remains relatively uncommon in consumer skincare products.

Tranexamoyl Dipeptide-22 is thought to work by interfering with the signalling pathways that trigger melanin synthesis in melanocytes (pigment-producing cells). The tranexamic acid component may inhibit plasmin and other enzymes involved in the inflammatory cascade that can stimulate pigmentation, whilst the peptide structure is designed to improve skin penetration and cellular communication.

If using a product containing this ingredient, apply it to cleansed skin as directed by the formulation. Results for hyperpigmentation typically develop over weeks to months of consistent use. Combine with sun protection (SPF 30 or higher daily) to prevent new pigmentation from forming, as UV exposure can counteract any tone-evening benefits.

Peptides are generally considered well-tolerated in skincare. Patch test first if you have sensitive skin or are prone to reactions. Discontinue use if irritation develops.