Peptides

Tranexamoyl Tetrapeptide-51

INCI: TRANEXAMOYL TETRAPEPTIDE-51

Reviewed by Daisy · Last updated 2 Jun 2026

Also known as: Tranexamoyl Tetrapeptide-51

A peptide derivative designed to support skin conditioning and resilience

Best For Skin Types

All, Sensitive, Dry, Combination

Addresses

Sensitivity, Barrier repair, Dryness, Redness

Usage Frequency

Daily

What Is Tranexamoyl Tetrapeptide-51?

Tranexamoyl tetrapeptide-51 is a synthetic peptide—a short chain of amino acids—modified with a tranexamic acid moiety. It functions as a skin-conditioning agent, working to support the skin's natural barrier and overall resilience.

Peptides in skincare are valued for their ability to communicate with skin cells and promote structural integrity. This particular ingredient combines peptide chemistry with tranexamic acid, an anti-inflammatory compound, to create a multifunctional conditioning agent.

How It Works

Tranexamoyl tetrapeptide-51 works through two mechanisms. The peptide portion can penetrate the outer layers of skin and signal to cells to support collagen and elastin production, contributing to skin firmness and structure. The tranexamic acid element provides anti-inflammatory action, which may help calm redness and support overall skin barrier health.

Together, these components aim to improve skin conditioning—leaving the skin feeling more resilient, hydrated, and comfortable.

Clinical Evidence & References

Research specifically targeting tranexamoyl tetrapeptide-51 is limited in the published literature. However, both peptides and tranexamic acid have independently demonstrated benefits in skincare formulations. Tranexamic acid is recognised for its anti-inflammatory and skin-soothing properties, whilst peptides are established for their role in supporting skin firmness and barrier function.

As a combined ingredient, tranexamoyl tetrapeptide-51 is likely to offer additive benefits, but robust clinical data on this specific molecule would help clarify its precise efficacy at typical cosmetic concentrations.

How to Use

This ingredient is typically found in serums, moisturisers, and treatment products. For best results, apply to clean skin morning and evening, or as directed by your product's instructions. It works well alongside other skin-conditioning and barrier-supporting ingredients. Allow each layer to absorb before applying additional products.

Safety & Precautions

Generally well-tolerated across skin types. Those with sensitivity to peptides or tranexamic acid should patch-test first. No major safety cautions reported at cosmetic use levels.

Frequently Asked Questions

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