Copper Tripeptide-1
Reviewed by Emma · Last updated 18 Aug 2026
Also known as: GHK-Cu, GHK-copper, copper peptides, GHK
Sends reparative signals to key proteins in skin’s extracellular matrix | Supports skin’s collagen, elastin, and glycosaminoglycans (such as hyaluronic acid)
Addresses
EWG Safety Score
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What Is Copper Tripeptide-1?
Copper tripeptide-1 is made up of three amino acids (glycine, histidine, and lysine) combined with the mineral copper. This complex is naturally present within bodily fluids, but as a skin care ingredient, it is created synthetically in the lab. In the most basic sense, it is categorized as a skin conditioning ingredient, but research indicates copper tripeptide-1 is capable of much more in terms of its anti-aging abilities. That said, the potential for increased hair growth while using products that contain this ingredient does limit the appeal of copper tripeptide-1 for some people, hence holding it back from receiving a BEST rating.
Copper tripeptide-1 is known as a signaling peptide due to the way it sends reparative signals by targeting key proteins in skin’s extracellular matrix. It is noted in research for supporting collagen and elastin production and increasing glycosaminoglycans (i.e. replenishing/hydrating substances like hyaluronic acid). This translates to benefits such as increasing skin’s firmness and density, while decreasing the appearance of fine lines/wrinkles. Research indicates it may also play a role in extending skin’s healthspan (also known as skin longevity). Additionally, copper tripeptide-1 has been shown to provide antioxidant and skin-soothing benefits.
We must also point out that the potential for hair growth stimulation is mentioned as a side effect in some studies of copper tripeptide-1. While that could be beneficial if you’re wanting to incite hair growth, on the flipside, it would be a deterrent if you do not want to stimulate hair growth (such as on the face) while using skin care products that contain copper tripeptide-1. Searching the web, anecdotal results are mixed regarding this matter. More studies are needed to conclusively rule on these findings.
The Cosmetics Ingredient Review 2018 safety assessment deemed copper tripeptide-1 safe as used in cosmetics. While their report did not call out recommended usage levels, suppliers of this ingredient suggest concentrations between 0.05-1%.
Benefits for Your Skin
Clinical Evidence & References
Published Research
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UL Prospector (supplier info), Accessed January 2023, ePublication [URL not found]
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International Journal of Molecular Sciences, July 2018, pages 1-13 [URL not found]
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International Journal of Toxicology, 2018, pages 90S-102S [URL not found]
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Cosmetics, May 2017, pages 1-14 [URL not found]
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BioMed Research International, July 2015, pages 1-7 [URL not found]
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Inflammation Research, January 2011, pages 79-86 [URL not found]
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Archives of Facial Plastic Surgery, January 2001, pages 28-32 [URL not found]
Frequently Asked Questions
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Collagen Water
A hydrating ingredient derived from broken-down collagen that supports skin moisture and suppleness
Colloidal Oatmeal Extract
A finely ground oat extract that soothes irritation and strengthens the skin barrier
Copper PCA
Synthetic skin-conditioning agent | Composed of the copper salt of PCA
Creatine
Amino acid found in the human body Serves as a precursor to adenosine triphosphate
Cucumis Melo Seed Oil
A lightweight plant oil that hydrates and conditions the skin
Cyclopia Intermedia Leaf Extract
South African honeybush extract with antioxidant and skin-conditioning properties
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