MATRIXYL Synthe6
INCI: Palmitoyl Tripeptide-38
Reviewed by Daisy · Last updated 18 Aug 2026
Also known as: Palmitoyl Tripeptide-38, Matrixyl Synthe 6
Matrix-supporting peptide for comprehensive wrinkle reduction
Addresses
EWG Safety Score
What Is MATRIXYL Synthe6?
MATRIXYL Synthe6 is a trademarked peptide based on Palmitoyl Tripeptide-38, designed to stimulate the synthesis of six major structural components of the skin matrix: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin-5.
This comprehensive approach addresses the multiple aspects of skin structure that decline with age, rather than targeting just one pathway. The result is a more complete anti-wrinkle action that addresses both surface and deep wrinkles.
Clinical studies have demonstrated significant improvements in wrinkle depth and volume with continued use of this advanced peptide.
From the Clinic
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